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Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis

Received: 21 December 2014     Accepted: 27 December 2014     Published: 14 March 2015
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Abstract

Many traditional medicines in use are obtained from medicinal plants, minerals and organic matter. During the past several years, there has been increasing interest among the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. Coccinia grandis has been used in traditional medicine as a household remedy for various diseases. The whole plant of Coccinia grandis having pharmacological activities like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial, antidyslipidemic, anticancer, antitussive, mutagenic. The present review gives botany, chemical constituents and pharmacological activities of coccinia grandis. This study was aimed to investigate the antidiabetic activities of methanolic extract of leaves, fruits, root and aerial part of Coccinia grandis in alloxan induced diabetic mice. Diabetes was confirmed after 25 days of single intraperitoneal injection of alloxan (150 mg/kg) in albino mice. Different groups of diabetic animals were treated with crude plant extract of 150 mg/kg , 300 mg/kg, 400 mg /kg respectively orally administered for a period of 8 hours. The blood sugar level was monitored after 2 hour, after 4 hour, after 6 hour and after 8 hour respectively. The antidiabetic effect of crude plant extract was compared with Glibenclamide (10 mg/kg) belongs to the group of oral hypoglycemic. Our study indicate that, the root, fruit, leaf and aerial part of plant extract (150 mg/kg) reduce the blood glucose level after 8th hour 7.87±0.35, 17.9±12.18, 19.5±7.04 and 23.7±7.23 respectively. The root, fruit, leaf and aerial part of plant extract (300 mg/kg) reduce the blood glucose level after 8th hour 18±12, 19.6±11.6, 20.1±1.55 and 15.3±1.28 respectively. The root, fruit, leaf and aerial part of plant extract (450 mg/kg) reduce the blood glucose level after 8th hour 16.2±1.08, 9.4±0.46, 14.3±1.31 and 10.4±1.56 respectively. Glibenclamide (10 mg/kg) reduces the blood glucose level 11.27±4.64. From this study, it was revealed that different part of Coccinia grandis plant extract has potential antidiabetic activity.

Published in Journal of Plant Sciences (Volume 2, Issue 6-1)

This article belongs to the Special Issue Pharmacological and Biological Investigation of Medicinal Plants

DOI 10.11648/j.jps.s.2014020601.14
Page(s) 19-23
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Alloxan, Coccinia grandis, Diabetes Mellitus, Glibenclamide, Hypoglycemic Activity

References
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[2] E. Edwin, E. Sheeja, S.P. Dhanabaland, and B. Suresh, “Antihyperglycemicactivity of Passifloramollissima Bailey,” Indian JournalofPharmaceuticalSciences, 2007, 64, p. 570–571.
[3] K.S. Vivek, K. Suresh, J.P. Hitesh and, and H. Schivakumar, “Hypoglycemicacitivity of Ficusglomerate in Alloxan induced diabeticrats,” International Journal of Pharmaceutical Sciences Reviewand Research, 2010, 1, p. 18–22.
[4] R.E. Lamb and B.J. Goldstein, “Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function,” Int J ClinPract, 2008, 62 (7), p. 1087–1095.
[5] J.S. Johansen, A.K. Harris, D.J. Rychly and A. Ergul, “Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice,” Cardiovasc Diabetol, 2005, 4(1), p.5.
[6] S. Wild, G. Roglic, A. Green, R. Sicreeand and H. King, “Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030,” DiabetesCare, 2004, 27, p.1047-1053.
[7] IDF Diabetes Atlas, 4th edition. International Diabetes Federation, 2009.
[8] American Diabetes Association,“Economic costs of diabetes in the USin 2002, Diabetes Care,” 2003, 26, p. 917-932.
[9] G. Chandramohan, S. Ignacimuthuand and K.V. Pugalendi, “A novel compound from Caseariae sculenta(Roxb.) root and its effect on carbohydrate metabolism in streptozotocin -diabetic rats,” EurJPharmacol, 2008, 590(1-3), p. 437-443.
[10] M. Yusuf, J.U. Chowdhury, M.A. Wahab and J. Begum, “Medicinal Plants of Bangladesh,” Bangladesh Council of Scientific and IndustrialResearch.Dhaka, 1994, p. -34.
[11] K.L. Joy and R. Kuttan, “Antidiabetic activity of Picrorrhiza kurroa extract,” J Ethanopharmacol, 1999, 67, p. 143–8.
[12] K.V. Pund, N.S. Vyawahare, R.T. Gadakh and V.K. Murkute, “Antidiabetic evaluation of DalbergiaSissooagainst alloxan induced diabetes mellitus in wistar albino rats,” Journal of Natural Product and Plant Resources, 2012, 2, p. 81-88.
[13] F.J. Alarcon-Aguilar, M. Jimenez-Estrada, R. Reyes-Chilpa, B. GonzalezParedes, C. Contreras-Weberand and R. Roman-Ramos, “Hypoglycemic activity of root water decoction, sesquierpenoids, and one Polysaccharide fraction from Psacaliumdecompositumin mice,” Journal of Ethno-Pharmacology, 2000, 69, p. 207-15.
[14] J.K. Grover, S. Yadav and V. Vats, “Medicinalplants of India with anti-diabetic potential,” J Ethanopharmacol, 2002, 81, p. 81-100.
[15] G.S. Viana, A.C. Medeiros, A.M. Lacerda, L.K. Leal, T.G. Vale and F.J. Matos, “Hypoglycemic and anti-lipemiceffects of the aqueous extract from Cissussicyoides,” BMC Pharmacol, 2004, 8, p. 4-9.
[16] L. Pari and M Latha, “Antidiabetic effect of Scopariadulcis:Effect of lipid peroxidation in Streptozotocin diabetes; Gen. Physiol,” Biophys, 2005, 24, p. 13-26.
Cite This Article
  • APA Style

    Md. Ataur Rahman, Jyotirmoy Sarker, Shamima Akter, Abdullah Al Mamun, Md. Abul Kalam Azad, et al. (2015). Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis. Journal of Plant Sciences, 2(6-1), 19-23. https://doi.org/10.11648/j.jps.s.2014020601.14

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    ACS Style

    Md. Ataur Rahman; Jyotirmoy Sarker; Shamima Akter; Abdullah Al Mamun; Md. Abul Kalam Azad, et al. Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis. J. Plant Sci. 2015, 2(6-1), 19-23. doi: 10.11648/j.jps.s.2014020601.14

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    AMA Style

    Md. Ataur Rahman, Jyotirmoy Sarker, Shamima Akter, Abdullah Al Mamun, Md. Abul Kalam Azad, et al. Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis. J Plant Sci. 2015;2(6-1):19-23. doi: 10.11648/j.jps.s.2014020601.14

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  • @article{10.11648/j.jps.s.2014020601.14,
      author = {Md. Ataur Rahman and Jyotirmoy Sarker and Shamima Akter and Abdullah Al Mamun and Md. Abul Kalam Azad and Md. Mohiuddin and Seuly Akter and Md. Shahid Sarwar},
      title = {Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis},
      journal = {Journal of Plant Sciences},
      volume = {2},
      number = {6-1},
      pages = {19-23},
      doi = {10.11648/j.jps.s.2014020601.14},
      url = {https://doi.org/10.11648/j.jps.s.2014020601.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.s.2014020601.14},
      abstract = {Many traditional medicines in use are obtained from medicinal plants, minerals and organic matter. During the past several years, there has been increasing interest among the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. Coccinia grandis has been used in traditional medicine as a household remedy for various diseases. The whole plant of Coccinia grandis having pharmacological activities like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial, antidyslipidemic, anticancer, antitussive, mutagenic. The present review gives botany, chemical constituents and pharmacological activities of coccinia grandis. This study was aimed to investigate the antidiabetic activities of methanolic extract of leaves, fruits, root and aerial part of Coccinia grandis in alloxan induced diabetic mice. Diabetes was confirmed after 25 days of single intraperitoneal injection of alloxan (150 mg/kg) in albino mice. Different groups of diabetic animals were treated with crude plant extract of 150 mg/kg , 300 mg/kg, 400 mg /kg   respectively orally administered for a period of 8 hours. The blood sugar level was monitored after 2 hour, after 4 hour, after 6 hour and after 8 hour respectively. The antidiabetic effect of crude plant extract was compared with Glibenclamide (10 mg/kg) belongs to the group of oral hypoglycemic. Our study indicate that, the root, fruit, leaf and aerial part of plant extract (150 mg/kg) reduce the  blood glucose level after 8th hour 7.87±0.35, 17.9±12.18, 19.5±7.04 and 23.7±7.23 respectively. The root, fruit, leaf and aerial part of plant extract (300 mg/kg) reduce the blood glucose level after 8th hour 18±12, 19.6±11.6, 20.1±1.55 and 15.3±1.28 respectively. The root, fruit, leaf and aerial part of plant extract (450 mg/kg) reduce the blood glucose level after 8th hour 16.2±1.08, 9.4±0.46, 14.3±1.31 and 10.4±1.56 respectively. Glibenclamide (10 mg/kg) reduces the blood glucose level 11.27±4.64. From this study, it was revealed that different part of Coccinia grandis plant extract has potential antidiabetic activity.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis
    AU  - Md. Ataur Rahman
    AU  - Jyotirmoy Sarker
    AU  - Shamima Akter
    AU  - Abdullah Al Mamun
    AU  - Md. Abul Kalam Azad
    AU  - Md. Mohiuddin
    AU  - Seuly Akter
    AU  - Md. Shahid Sarwar
    Y1  - 2015/03/14
    PY  - 2015
    N1  - https://doi.org/10.11648/j.jps.s.2014020601.14
    DO  - 10.11648/j.jps.s.2014020601.14
    T2  - Journal of Plant Sciences
    JF  - Journal of Plant Sciences
    JO  - Journal of Plant Sciences
    SP  - 19
    EP  - 23
    PB  - Science Publishing Group
    SN  - 2331-0731
    UR  - https://doi.org/10.11648/j.jps.s.2014020601.14
    AB  - Many traditional medicines in use are obtained from medicinal plants, minerals and organic matter. During the past several years, there has been increasing interest among the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. Coccinia grandis has been used in traditional medicine as a household remedy for various diseases. The whole plant of Coccinia grandis having pharmacological activities like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial, antidyslipidemic, anticancer, antitussive, mutagenic. The present review gives botany, chemical constituents and pharmacological activities of coccinia grandis. This study was aimed to investigate the antidiabetic activities of methanolic extract of leaves, fruits, root and aerial part of Coccinia grandis in alloxan induced diabetic mice. Diabetes was confirmed after 25 days of single intraperitoneal injection of alloxan (150 mg/kg) in albino mice. Different groups of diabetic animals were treated with crude plant extract of 150 mg/kg , 300 mg/kg, 400 mg /kg   respectively orally administered for a period of 8 hours. The blood sugar level was monitored after 2 hour, after 4 hour, after 6 hour and after 8 hour respectively. The antidiabetic effect of crude plant extract was compared with Glibenclamide (10 mg/kg) belongs to the group of oral hypoglycemic. Our study indicate that, the root, fruit, leaf and aerial part of plant extract (150 mg/kg) reduce the  blood glucose level after 8th hour 7.87±0.35, 17.9±12.18, 19.5±7.04 and 23.7±7.23 respectively. The root, fruit, leaf and aerial part of plant extract (300 mg/kg) reduce the blood glucose level after 8th hour 18±12, 19.6±11.6, 20.1±1.55 and 15.3±1.28 respectively. The root, fruit, leaf and aerial part of plant extract (450 mg/kg) reduce the blood glucose level after 8th hour 16.2±1.08, 9.4±0.46, 14.3±1.31 and 10.4±1.56 respectively. Glibenclamide (10 mg/kg) reduces the blood glucose level 11.27±4.64. From this study, it was revealed that different part of Coccinia grandis plant extract has potential antidiabetic activity.
    VL  - 2
    IS  - 6-1
    ER  - 

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Author Information
  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

  • Department of Pharmacy, Southeast University, Dhaka, Bangladesh

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