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Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients

Received: 21 June 2013     Published: 10 July 2013
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Abstract

This retrospective report presents findings on 7 patients with idiopathic dilated cardiomyopathy who underwent transplantation of autologous bone marrow derived mononuclear cells (BMSC) after failed routine conservative treatment, and were on a waiting list for cardiac transplantation. In two out of seven patients, we performed intramyocardial delivery of BMSC twice, 22 and 24 months respectively after the first transplant. All patients received anti-congestive therapy by diu-retics, ACE inhibitors, carvedilol, digitalis and aspirin. We discuss potential disadvantages of intracoronary injections of autologous bone marrow stem cells. We believe that our BMSC transplantation method as opposed to intravascular input is the method of choice, particularly in children with idiopathic dilated cardiomyopathy because it is safe, gentle and is not associated with risks for coronary circulation.

Published in Science Journal of Clinical Medicine (Volume 2, Issue 4)
DOI 10.11648/j.sjcm.20130204.12
Page(s) 129-133
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Idiopathic Dilated Cardiomyopathy (IDCM) In Children, Bone Marrow Stem Cells (BMSC), Intramyocardial BMSC Transplantation

References
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Cite This Article
  • APA Style

    Aris Lacis, Inguna Lubaua, Andrejs Erglis, Andis Lacis, Inta Bergmane. (2013). Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients. Science Journal of Clinical Medicine, 2(4), 129-133. https://doi.org/10.11648/j.sjcm.20130204.12

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    ACS Style

    Aris Lacis; Inguna Lubaua; Andrejs Erglis; Andis Lacis; Inta Bergmane. Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients. Sci. J. Clin. Med. 2013, 2(4), 129-133. doi: 10.11648/j.sjcm.20130204.12

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    AMA Style

    Aris Lacis, Inguna Lubaua, Andrejs Erglis, Andis Lacis, Inta Bergmane. Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients. Sci J Clin Med. 2013;2(4):129-133. doi: 10.11648/j.sjcm.20130204.12

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  • @article{10.11648/j.sjcm.20130204.12,
      author = {Aris Lacis and Inguna Lubaua and Andrejs Erglis and Andis Lacis and Inta Bergmane},
      title = {Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients},
      journal = {Science Journal of Clinical Medicine},
      volume = {2},
      number = {4},
      pages = {129-133},
      doi = {10.11648/j.sjcm.20130204.12},
      url = {https://doi.org/10.11648/j.sjcm.20130204.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20130204.12},
      abstract = {This retrospective report presents findings on 7 patients with idiopathic dilated cardiomyopathy who underwent transplantation of autologous bone marrow derived mononuclear cells (BMSC) after failed routine conservative treatment, and were on a waiting list for cardiac transplantation. In two out of seven patients, we performed intramyocardial delivery of BMSC twice, 22 and 24 months respectively after the first transplant. All patients received anti-congestive therapy by diu-retics, ACE inhibitors, carvedilol, digitalis and aspirin. We discuss potential disadvantages of intracoronary injections of autologous bone marrow stem cells. We believe that our BMSC transplantation method as opposed to intravascular input is the method of choice, particularly in children with idiopathic dilated cardiomyopathy because it is safe, gentle and is not associated with risks for coronary circulation.},
     year = {2013}
    }
    

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    T1  - Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients
    AU  - Aris Lacis
    AU  - Inguna Lubaua
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    AU  - Inta Bergmane
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    N1  - https://doi.org/10.11648/j.sjcm.20130204.12
    DO  - 10.11648/j.sjcm.20130204.12
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    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
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    UR  - https://doi.org/10.11648/j.sjcm.20130204.12
    AB  - This retrospective report presents findings on 7 patients with idiopathic dilated cardiomyopathy who underwent transplantation of autologous bone marrow derived mononuclear cells (BMSC) after failed routine conservative treatment, and were on a waiting list for cardiac transplantation. In two out of seven patients, we performed intramyocardial delivery of BMSC twice, 22 and 24 months respectively after the first transplant. All patients received anti-congestive therapy by diu-retics, ACE inhibitors, carvedilol, digitalis and aspirin. We discuss potential disadvantages of intracoronary injections of autologous bone marrow stem cells. We believe that our BMSC transplantation method as opposed to intravascular input is the method of choice, particularly in children with idiopathic dilated cardiomyopathy because it is safe, gentle and is not associated with risks for coronary circulation.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Clinic of Pediatric Cardiology and Cardiac Surgery, University Children Hospital, Riga, Latvia

  • Riga Stradins University, Riga, Latvia

  • Latvian Institute of Cardiology, Riga, Latvia

  • Riga Stradins University, Riga, Latvia

  • Clinic of Pediatric Cardiology and Cardiac Surgery, University Children Hospital, Riga, Latvia

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